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Perform by Other people, including Dickey, has proven that upsized mucin secretion in the airways will work in Substantially the identical way, involving analogous vesicles (full of mucin in place of neurotransmitters) and synaptotagmin and collaborating proteins.
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Brunger’s and Dickey’s groups created a little protein snippet, or peptide, identified as SP9, that blocked synaptotagmin’s calcium-brought on sp9 interaction with its cooperating proteins in mice.
That has a Exclusive provider area additional to its sequence, the peptide efficiently entered the cells. When the cells were being stimulated to secrete mucin, SP9 lowered secretion by 83%.
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